A

AutoPVS1 Link

Verified Integration
Author: @spawningCategory: ServerApplication
JSON-RPC 2.0
Protocol Standard
Sub-second
Execution Latency
Active
Operational Status

Client Configuration

— Connect AutoPVS1 Link to Claude Desktop or Cursor in seconds
{
  "mcpServers": {
    "autopvs1-link": {
      "command": "npx",
      "args": [
        "-y",
        "@modelcontextprotocol/server-autopvs1-link"
      ],
      "env": {}
    }
  }
}
Paste into ~/Library/Application Support/Claude/claude_desktop_config.json (macOS) or %APPDATA%\Claude\claude_desktop_config.json (Windows).
Architecture & Capabilities

System Overview

Provides automated ACMG PVS1 loss-of-function evidence for sequence and copy-number variants, serving as a typed tool for LLM agents.

Indexed Date

7/22/2026

License

Open Source

Protocol Layer

stdio / SSE RPC

Frequently Asked Questions

Architecture and operational details for AutoPVS1 Link

It employs robust scraping with parsers pinned to HTML fixtures, ensuring that changes to the upstream AutoPVS1 website fail CI rather than causing silent data errors. It also implements caching (default 24h TTL) and a 1.0s rate-limiting delay to prevent overwhelming the AutoPVS1 service.

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